08 Jan
clinical trial
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nutrition
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plant substances
Red wine drinkers are generally good-natured people and known for mastering life with pleasure and relaxation. These alone are two protective factors against dementia, because stress is poison for the brain (but more about this later on). In addition, a secondary plant substance present particularly in red wine is increasingly attracting the interest of research and prevention in Alzheimer's disease: resveratrol.
18 Dec
clinical trial
,
Forms of treatment
,
medication
Lanabecestat is a potent inhibitor of Amyloid beta (Aβ) formation – the main component of amyloid plaques. Aβ is formed through cleavage of amyloid precursor protein (APP) by proteases known as secretases (β and γ). The Beta-site-APP-cleaving enzyme 1 (BACE1) cleaves APP at the β-secretase site, after which APP is cleaved by γ secretase to generate Aβ peptides. Lanabecestat inhibits BACE1 and was able to reduce levels of Aβ1-40 and Aβ1-42 in the brain, cerebrospinal fluid (CSF), and plasma in several animal models, as well as in human CSF and plasma. Besides that, Lanabecestat is brain permeable meaning that an adequate amount of this substance is able to reach the brain after oral intake.
27 Nov
Causes
,
Forms of treatment
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micronutrient deficiencies
,
nutrition
This descriptive documentation of the Arte TV channel shows very clearly the connections between an unbalanced diet, the resulting micronutrient deficiencies and the effects on the brain. Various experiments have shown that mice that grow up with a deficiency of omega-3 fatty acids have deficits in the formation of their neurons and are much more anxious.
13 Nov
Causes
,
periodontosis
The association between cognitive function and oral health has been well documented so far by some observational studies. On the one hand it has been reported that periodontal disease and tooth loss are associated with increased risk of dementia. On the other hand, improved memory after dental intervention has also been observed.
25 Oct
medication
Several million patients in Germany are treated with statins. In 2004, the consumption of lipid-lowering drugs throughout Germany amounted to around 856 million defined daily doses (DDD). In 2011 the amount increased to: 1.718 million DDD.
With the target to lower cholesterol levels, this doubtful strategy is still being mistakenly promoted to reduce heart disease risk. As a side effect, doctors and patients are accepting a possible cognitive decline.
These are the results of a study published in 2018 in the journal Frontiers in Neurology, which looked into the relationship between cholesterol and cognitive function [1]. While cholesterol is still largely vilified, and statin use still heavily promoted, the study found that having lower levels of low-density lipoprotein (LDL) cholesterol is linked to a higher risk of dementia.
04 Oct
Causes
The focus of Alzheimer’s research has been, so far, the molecular process which leads to a change in the brain structure, above all and first in the hippocampus. Here, an increased formation of amyloid beta (Aß) plaques is observed in the brains of Alzheimer patients. These protein adhesions impair the communication between nerve cells. Such alterations are attributed to ageing and genetic predisposition. As a result, Alzheimer’s research has been searching for years (but without any success) for a drug therapy to eliminate or at least reduce plaque formation. A very monocausal view of the problem.
25 Jul
nutrition
,
plant substances
The benefits of curcumin in different organ systems have been extensively documented in the past in several neurological diseases and cancer. Curcumin has received worldwide recognition for its potent antioxidant, anti-inflammatory, anti-cancer and antimicrobial activities. Curcumin has been successfully used to treat diabetes and arthritis, as well as liver, kidney and cardiovascular diseases. Recently, attention has focused on the use of curcumin to prevent or delay the onset of neurodegenerative diseases.
26 Jun
Forms of treatment
Despite the significant health problem posed by the disease, only five medical treatments are approved for Alzheimer's disease (AD), which are intended to control symptoms rather than change the course of the disease. By understanding the overlapping mechanisms of AD pathology, it is possible to get an idea of the complexity of this problem.
11 Jun
Uncategorized
The World Health Organization has recognized that dementia is a rapidly growing public health problem affecting some 50 million people around the world. There are nearly 10 million new cases per year, and this number is expected to triple by 2050.
Dementia is a major cause of disability and need for care among older people and can destroy the lives of those affected and their families. In addition, the disease places a heavy economic burden on society as a whole, with the cost of caring for people with dementia estimated to rise to $2 trillion annually by 2030.